Paul Rothemund and Colleagues Use Self-Assembled DNA Scaffolding to Build Tiny Circuit Boards
Dr. Paul Rothemund, Senior Research Associate in Bioengineering, Computer Science, and Computation and Neural Systems, and colleagues have developed a new technique to orient and position self-assembled DNA shapes and patterns--or "DNA origami"--on surfaces that are compatible with today's semiconductor manufacturing equipment. They "have removed a key barrier to the improvement and advancement of computer chips. They accomplished this through the revolutionary approach of combining the building blocks for life with the building blocks for computing," said Professor Ares Rosakis, Chair of Division of Engineering and Applied Science and Theodore von Kármán Professor of Aeronautics and Mechanical Engineering. [Caltech Press Release]
Michael Hucka and Colleagues Help Launch the First Standard Graphical Notation for Biology
Dr. Michael Hucka, Senior Research Fellow in Control and Dynamical Systems and Co-Director of the Biological Network Modeling Center, and colleagues in 30 laboratories worldwide have released a new set of standards for graphically representing biological information—the biology equivalent of the circuit diagram in electronics. This visual language should make it easier to exchange complex information, so that biological models are depicted more accurately, consistently, and in a more readily understandable way. The new standard, is called the Systems Biology Graphical Notation (SBGN). "As biology focuses more on managing complexity with quantitative and systematic methods, standards such as SBGN play an essential role. SBGN combines an intuitive notation with the rigorous style of engineering and math," says John Doyle, the John G. Braun Professor of Control and Dynamical Systems, Bioengineering, and Electrical Engineering. [Caltech Press Release]
President Obama Presents Three EAS Faculty with the PECASE
In a special White House ceremony, President Obama will be presenting three EAS faculty: John Dabiri, Assistant Professor of Aeronautics and Bioengineering, Beverley McKeon, Assistant Professor of Aeronautics, and Joel Tropp, Assistant Professor of Applied and Computational Mathematics, with the Presidential Early Career Awards for Scientists and Engineers (PECASE). "These extraordinarily gifted young scientists and engineers represent the best in our country," President Obama said. Dabiri,describes the idea behind his PECASE-winning research as "giving underwater vehicles the enhanced performance of fish (e.g. efficiency, stealth, and maneuverablity) without mimicking the shape and swimming motions of fish. Instead, we replicate the vortex dynamics in the wakes of swimming fish." His "bio-inspired systems" were used by Lydia Ruiz (PhD '09 Mechanical Engineering), to demonstrateincreases in vehicle propulsive efficiency of over 50 percent.
McKeon is receiving the PECASE for her research on fundamental questions in complex turbulent boundary layers. McKeon states that "the ultimate goal is to incorporate recent advances in the understanding of flow physics in order to develop low order models of flow over surfaces for Air Force applications". Tropp's PECASE-winning research "focuses on developing new algorithms for solving inverse problems, a basic challenge that arises throughout the mathematical sciences. Inverse problems also appear in medical imaging, in communication systems, in statistical data analysis, and a host of other areas." He uses tools from modern applied mathematics, such as optimization techniques and randomized algorithms to collect partial information about an object of interest, and incorporate additional background knowledge to develop a complete picture of the object.
Other researchers receiving the PECASE award this year are Joshua K. Willis from the Jet Propulsion Laboratory and the following Caltech Alumni Elizabeth Boon, (PhD '03 CCE), Markus J. Buehler, (Post doc in CCE) Michael J. Hochberg, (Ph.D. '06 EAS - Applied Physics), Justin K. Romberg, (Post doc in EAS - Applied and Computational Mathematics), Cecilia R. Aragon, (B.S. '82 PMA), Jason Graetz, (Ph.D. '03 EAS - Materials Science), and Ioannis Chasiotis, (Ph.D. '02 EAS - Aerospace).