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A Microscopic Glowing Van Gogh

07-12-16

Paul Rothemund, Research Professor of Bioengineering, Computing and Mathematical Sciences, and Computation and Neural Systems, and colleagues have developed a technique that allows manmade DNA shapes to be placed wherever desired; to within a margin of error of just 20 nanometers. This technique removes a major hurdle for the large-scale integration of molecular devices on chips. As a demonstration of the technique’s capabilities the group has created one of the world's smallest reproductions of Vincent van Gogh's The Starry Night. [Caltech story]

Tags: research highlights CMS Paul Rothemund

DNA Origami: Folded DNA as a Building Material for Molecular Devices

05-20-16

Paul Rothemund, Research Professor of Bioengineering, Computing and Mathematical Sciences, and Computation and Neural Systems, explains how his group and groups around the world are using DNA origami in applications ranging from potential cancer treatments to devices for computing. [Caltech interview]

Tags: research highlights CMS Paul Rothemund

Programmed to Fold: RNA Origami

08-20-14

Paul Rothemund, Senior Research Associate in Bioengineering, Computer Science, and Computation and Neural Systems, and colleagues have fabricated complicated shapes from DNA's close chemical cousin, RNA. "RNA origami is still in its infancy," says Rothemund. "Nevertheless, I believe that RNA origami, because of their potential to be manufactured by cells, and because of the extra functionality possible with RNA, will have at least as big an impact as DNA origami." [Caltech Release]

Tags: EE research highlights health CMS Paul Rothemund

Developing Self-replicating Nanoscale Origami

08-06-13

William A. Goddard III, Charles and Mary Ferkel Professor of Chemistry, Materials Science, and Applied Physics, and colleagues including Postdoctoral Scholar Si-ping Han have been awarded a $2 million grant as part of the National Science Foundation’s Origami Design for Integration of Self-assembling Systems for Engineering Innovation program. The funds will be used to develop biomimetic materials which contain assembled complexes of molecules that self-replicate, evolve and adopt intricate three dimensional structures at the nanometer scale by combining DNA guided self-assembly with origami folding.

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Tags: APhMS research highlights health William Goddard Paul Rothemund Si-ping Han

DNA Origami Nanoscale Breadboards for Carbon Nanotube Circuits

11-10-09

Hareem T. Maune, a graduate student studying carbon nanotube physics, and Si-ping Han, a graduate student investigating the interactions between carbon nanotubes and DNA have developed DNA origami nanoscale breadboards for carbon nanotube circuits. "This collaborative research project is evidence of how we at Caltech select the top students in science and engineering and place them in an environment where their creativity and imagination can thrive," says Ares Rosakis, chair of the Division of Engineering and Applied Science at Caltech and Theodore von Kármán Professor of Aeronautics and Professor of Mechanical Engineering. The work of these students was supervised by: Erik Winfree, Associate Professor of Computer Science, Computation and Neural Systems, and Bioengineering; William A. Goddard III, Charles and Mary Ferkel Professor of Chemistry, Materials Science, and Applied Physics; Paul W.K. Rothemund, Senior Research Associate, and Marc Bockrath, Associate Professor of Physics at University of California Riverside. [Caltech Press Release]

Tags: APhMS research highlights CMS Erik Winfree William Goddard Paul Rothemund Si-ping Han

Paul Rothemund and Colleagues Use Self-Assembled DNA Scaffolding to Build Tiny Circuit Boards

08-18-09

Dr. Paul Rothemund, Senior Research Associate in Bioengineering, Computer Science, and Computation and Neural Systems, and colleagues have developed a new technique to orient and position self-assembled DNA shapes and patterns--or "DNA origami"--on surfaces that are compatible with today's semiconductor manufacturing equipment. They "have removed a key barrier to the improvement and advancement of computer chips. They accomplished this through the revolutionary approach of combining the building blocks for life with the building blocks for computing," said Professor Ares Rosakis, Chair of Division of Engineering and Applied Science and Theodore von Kármán Professor of Aeronautics and Mechanical Engineering. [Caltech Press Release]

Tags: EE research highlights health CMS Paul Rothemund

Roukes and Rothemund Display Work at MoMA

04-10-08

"If you make structures that are impeccably designed, they also often tend to work really well," says Michael Roukes, Professor of Physics, Applied Physics, and Bioengineering. He along with senior research associate in computation and neural systems and computer science Paul Rothemund are scientists who can now add artist to their resumes. Rothemund's DNA origami and a colorized electron micrograph of Roukes's nanoscience work were displayed in Design and the Elastic Mind at the Museum of Modern Art (MoMA) in New York. Roukes's micrograph was even selected for the museum's permanent collection. [Caltech Press Release]

Tags: APhMS research highlights health Michael Roukes Paul Rothemund