Paul Rothemund Places Molecule-Scale Devices in Precise Orientation

Paul Rothemund, Research Professor of Bioengineering, Computing and Mathematical Sciences, and Computation and Neural Systems, has developed a technique that allows him to precisely place microscopic devices formed from folded DNA molecules in not only a specific location but also in a specific orientation. This method for precisely placing and orienting DNA-based molecular devices may make it possible to use these molecular devices to power new kinds of chips that integrate molecular biosensors with optics and electronics for applications such as DNA sequencing or measuring the concentrations of thousands of proteins at once. [Caltech story]