Lior Pachter
Bren Professor of Computational Biology and Computing and Mathematical Sciences
B.S., Caltech, 1994; Ph.D., Massachusetts Institute of Technology, 1999. Bren Professor, Caltech, 2017-.
Overview
Professor Patcher is a computational biologist working in genomics. His career began in comparative genomics, and initially was interested in genome alignment, annotation, and the determination of conserved regions using phylogenetic methods. More recently he's become focused on functional genomics, which includes answering questions about the function and interaction of DNA, RNA and protein products. He's particularly interested in applications of high-throughput sequencing to RNA biology. Genomics requires the development of algorithms, statistical methodology and mathematical foundations, and a major part of his research is therefore on methods.
Publications
- Sullivan, Delaney K.;Pachter, Lior (2024) Flexible parsing, interpretation, and editing of technical sequences with splitcodeBioinformatics
- Dorff, Tanya B.;Blanchard, M. Suzette et al. (2024) PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trialNature Medicine
- Sierra, Noemie;Olsman, Noah et al. (2024) A novel approach to comparative RNA-Seq does not support a conserved set of orthologs underlying animal regenerationGenome Biology and Evolution
- Rich, Joseph M.;Moses, Lambda et al. (2024) The impact of package selection and versioning on single-cell RNA-seq analysis
- Booeshaghi, Ali Sina;Chen, Xi et al. (2024) A machine-readable specification for genomics assaysBioinformatics
- Booeshaghi, A. Sina;Galvez-Merchán, Ángel et al. (2024) Algorithms for a Commons Cell Atlas
- Galvez-Merchán, Ángel;Booeshaghi, A. Sina et al. (2024) A human commons cell atlas reveals cell type specificity for OAS1 isoforms
- Luebbert, Laura;Hoang, Chi et al. (2024) Fast and scalable querying of eukaryotic linear motifs with gget elmBioinformatics
- Gorin, Gennady;Pachter, Lior (2024) New and notable: Revisiting the "two cultures" through extrinsic noiseBiophysical Journal
- Booeshaghi, A. Sina;Min, Kyung Hoi (Joseph) et al. (2024) Quantifying orthogonal barcodes for sequence census assaysBioinformatics Advances
Related Courses
2022-23
Bi/BE/CS 183 – Introduction to Computational Biology and Bioinformatics
2021-22
Bi/BE/CS 183 – Introduction to Computational Biology and Bioinformatics
2020-21
CMS/CS/CNS/EE/IDS 155 – Machine Learning & Data Mining
Bi/BE/CS 183 – Introduction to Computational Biology and Bioinformatics