Niles A. Pierce
John D. and Catherine T. MacArthur Professor of Applied and Computational Mathematics and Bioengineering; Executive Officer for Biology and Biological Engineering
B.S.E., Princeton University, 1993; D.Phil., University of Oxford, 1997. Assistant Professor, Caltech, 2000-06; Associate Professor, 2006-10; Professor, 2010-24; MacArthur Professor, 2024-; Acting Executive Officer, 2007; Executive Officer, 2007-13, 2020-.
Research interests: biological engineering, chemical engineering, computational mathematics, molecular programming, chemical biology, synthetic biology
Overview
Engineering small conditional DNAs and RNAs for signal transduction in vitro, in situ, and in vivo; computational algorithms for the analysis and design of nucleic acid structures, devices, and systems; programmable molecular technologies for readout and regulation of the state of endogenous biological circuitry.
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- Schulte, Samuel J.;Shin, Boyoung et al. (2024) Multiplex, Quantitative, High-Resolution Imaging of Protein:Protein Complexes via Hybridization Chain ReactionACS Chemical Biology
- Schulte, Samuel J.;Fornace, Mark E. et al. (2024) HCR spectral imaging: 10-plex, quantitative, high-resolution RNA and protein imaging in highly autofluorescent samplesDevelopment
- Schulte, Samuel J.;Huang, Jining et al. (2023) Hybridization Chain Reaction Lateral Flow Assays for Amplified Instrument-Free At-Home SARS-CoV-2 TestingACS Infectious Diseases
- Fornace, Mark E.;Huang, Jining et al. (2022) NUPACK: Analysis and Design of Nucleic Acid Structures, Devices, and Systems
- Bokhari, Rihana S.;Beheshti, Afshin et al. (2022) Looking on the Horizon; Potential and Unique Approaches to Developing Radiation Countermeasures for Deep Space TravelLife Sciences in Space Research
- Schulte, Samuel J.;Huang, Jining et al. (2022) HCR Lateral Flow Assays for Amplified Instrument-Free At-Home SARS-CoV-2 Testing
- Schwarzkopf, Maayan;Liu, Mike C. et al. (2021) Hybridization chain reaction enables a unified approach to multiplexed, quantitative, high-resolution immunohistochemistry and in situ hybridizationDevelopment
- Hochrein, Lisa M.;Li, Heyun et al. (2021) High-Performance Allosteric Conditional Guide RNAs for Mammalian Cell-Selective Regulation of CRISPR/CasACS Synthetic Biology
- Fornace, Mark E.;Porubsky, Nicholas J. et al. (2020) A Unified Dynamic Programming Framework for the Analysis of Interacting Nucleic Acid Strands: Enhanced Models, Scalability, and SpeedACS Synthetic Biology
- Schwarzkopf, Maayan;Choi, Harry M. T. et al. (2020) Multiplexed Quantitative In Situ Hybridization for Mammalian Cells on a Slide: qHCR and dHCR Imaging (v3.0)